Ardiansyah, Ardiansyah and Shirakawa, Hitoshi and Komai, Michio (2013) Identification of novel physiological effect of oral administration of ferulic acid on hepatic gene expression in stroke-prone spontaneously hypertensive rats. In: Advancing Vaccines in the Genomics Era-Keystone Symposia on Molecular and Cellular Biology, 31 October – 4 November 2013, Rio de Janeiro, Brazil.
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Abstract
Ferulic acid (FA, 4-hydroxy-3-methoxycinnamic acid) is the most abundant hydroxycinnnamic acid in the plant kingdom. FA is essentially found in the bran of grain and hence it is a suitable raw material for the production of FA. FA is known to be a high antioxidant, an effective scavenger of free radicals, and it lowers blood glucose level in streptozotocin-induced diabetic rats and blood pressure (BP) in spontaneously hypertensive rats. This study was aimed to investigate the effects of single oral administration of FA to reduce BP and improve lipid levels in stroke-prone spontaneously hypertensive rats (SHRSP). Male 12-week-old of SHRSP was administered FA or distilled water (control) via a gastric tube. The BP was measured before and 1,2,4, and 6 h after the administration. After 5 days, the rats were administered again with the same procedure and were sacrificed 2 h after the administration. The DNA microarray technique was used to identify novel physiological effect of FA on hepatic gene expression. Hypotensive effect was observed after 1,2 and 4 h, and back to the basal condition after 6 h; with the lowest value at 2 h. Decrease of the angiotensin-1 converting enzyme (ACE) activity in plasma corresponded well to the reduction of BP 2 h after the oral administration. Plasma total cholesterol and triglyceride levels were lower after 2 h the administration. The mRNA expression of genes involved in the lipid, glucose, and drug metabolisms were down-regulated in FA group. These results suggested that oral administration of FA appears to have a beneficial activity to improve hypertension and hyperlipidemia.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Subjects: | Medicine > R Medicine (General) |
| Divisions: | Fakultas Teknik dan Ilmu Komputer > Program Studi Ilmu dan Teknologi Pangan |
| Depositing User: | Ali Syahbana |
| Date Deposited: | 21 Jun 2017 01:32 |
| Last Modified: | 21 Jun 2017 01:32 |
| URI: | http://repository.bakrie.ac.id/id/eprint/785 |
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