Ardiansyah, Ardiansyah and Shirakawa, Hitoshi and Koseki, Takuya and Komai, Michio (2015) Functional Properties of Rice Bran Fraction to Improve Life-Style Related Diseases in Stroke-Prone Spontaneously Hypertensive Rats. In: Seminar Nasional Pangan Fungsional & Kick off P3FNI, 12 Desember 2015, Jogjakarta.
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Abstract
Rice bran is an underutilized by-product of the rice milling process that has potential as a rich source of bioactive compounds which have beneficial effects on human health. The purpose of the present study was to identify the effect of dietary supplementation of rice bran treated with Driselase (DF)—a mixture of plant cell walldegrading enzymes including cellulases, xylanases, and laminarinases-on metabolic syndrome-related parameters in stroke-prone spontaneously hypertensive rats (SHRSP). Male 4-week-old rats were divided into control group fed based on AIN-93 M diet, and the other two groups were fed diet supplemented with DF and ethanol fractions of rice bran. After 8 weeks feeding, supplementation the DF of rice bran had protective effects against hypertension, hyperglycemia, and hyperlipidemia parameters. By NMR analyses, the active compound was identified as adenosine, and it improved hypertension and the plasma triglyceride, glucose, and nitric oxide levels after 2 h of single administration. Furthermore, the effects of chronic adenosine administration in SHRSP after high-fat diet intake were studied. Hypertension, hyperglycemia, and hyperlipidemia were significantly improved in the adenosine-fed group. Administration of adenosine increased in plasma adiponectin levels, accompanied by upregulation of mRNA expression level of adiponectin and adiponectin receptor l in perirenal fat and adiponectin receptor 2 in the liver. In conclusion, DF has beneficial as dietary component to improve metabolic syndrome-related parameters in SHRSP.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Uncontrolled Keywords: | Keywords: rice bran, hypertension, hyperglycemia, hyperlipidemia, SHRSP |
| Subjects: | Food Science and Technology |
| Divisions: | Fakultas Teknik dan Ilmu Komputer > Program Studi Ilmu dan Teknologi Pangan |
| Depositing User: | Ali Syahbana |
| Date Deposited: | 21 Jun 2017 03:03 |
| Last Modified: | 21 Jun 2017 03:03 |
| URI: | http://repository.bakrie.ac.id/id/eprint/787 |
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