Germinated IR-64 brown rice improves hyperglycemia in diabetic rats

Dini, Umi Kartika and Mayangsari, Yunika and Ardiansyah, Ardiansyah and Shirakawa, Hitoshi and Saputra, Wahyu Dwi (2024) Germinated IR-64 brown rice improves hyperglycemia in diabetic rats. Nutrire, 49 (49). ISSN 2316-7874

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Abstract

Purpose Brown rice (BR) has been recognized as a promising agent for attenuating type 2 diabetes mellitus (T2DM). However, the in vivo effects of germinated brown rice (GBR) varieties, specifically IR-64, on diabetic conditions remain unexplored. This study aimed to evaluate the antidiabetic potential of IR-64 GBR in streptozotocin-nicotinamide (STZ-NA)-induced Wistar rats over a 24-day experimental period. Methods Wistar rats were randomly assigned to one of four groups: control, T2DM, BR, or GBR. The T2DM, BR, and GBR groups were intraperitoneally injected with STZ (45 mg/kg) or NA (110 mg/kg) to induce diabetes. The control group received a standard AIN93M diet, whereas the BR and GBR groups were fed AIN93M diets supplemented with BR and GBR, respectively, adjusted for total calories and fiber content. The study lasted over a 24 days. Results Blood glucose levels were significantly lower in the GBR group than those in in the T2DM group. Furthermore, the GBR group demonstrated increased insulin secretion and improved pancreatic β-cell structure. Conclusion These findings suggest that IR-64 GBR has the potential to mitigate the risk of T2DM through its antidiabetic properties, highlighting its beneficial effects in managing diabetes.

Item Type:	Article
Subjects:	Medicine > RD Surgery
Divisions:	Fakultas Teknik dan Ilmu Komputer > Program Studi Ilmu dan Teknologi Pangan
Depositing User:	Ahmad Yani
Date Deposited:	10 Oct 2024 06:14
Last Modified:	10 Oct 2024 06:22
URI:	https://repository.bakrie.ac.id/id/eprint/10995

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