In vivo evaluation of germinated IR-64 brown rice dietary administration on the lipid blood profiles of rats with hypercholesterolemia

Mantiri, Sisilia Anisa and Mayangsari, Yunika and Ardiansyah, Ardiansyah and Shirakawa, Hitoshi and Saputra, Dwi Saputra (2024) In vivo evaluation of germinated IR-64 brown rice dietary administration on the lipid blood profiles of rats with hypercholesterolemia. Nutrire, 49 (44). ISSN 2316-7874

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Abstract

Purpose Germination is a natural process that enhances the bioactive compounds and the antioxidant properties of brown rice. This study investigated the effects of germination on the total phenolic content (TPC) and antioxidant activities of IR-64 brown rice. The effect of germinated IR-64 brown rice on body weight, feed consumption, blood lipid profile, malondialdehyde (MDA) levels, and liver histopathology were evaluated in rats with hypercholesterolemia. Method IR-64 brown rice was germinated for 72 and 96 h. TPC analysis was conducted using the Folin–Ciocalteu method, and the antioxidant activity was assessed using the 2,2-diphenyl-1-picrylhydrazyl, 2,2-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid radical cation, and ferric reducing antioxidant power methods. In vivo analysis involved 28 Sprague–Dawley rats divided into four groups: Group I, the normal was fed, AIN-93 M; Group II, the HFD, was fed a high-fat diet; Group III, was the brown rice, was fed a high-fat diet and IR-64 brown rice; and Group IV, the germinated brown rice, was fed a high-fat diet and germinated IR-64 brown rice -with the intervention period lasting 28 days. Parameters of body weight, food consumption, blood lipid profile, MDA levels, and liver histopathology of rat was observed. Result An increase was observed in the TPC and antioxidant activity of germinated IR-64 brown rice. Administration of germinated IR-64 brown rice to rats who received a high-fat diet demonstrated its ability to significantly maintain body weight and reduce total cholesterol, triglycerides, low-density lipoprotein cholesterol, and MDA levels. Germinated IR-64 brown rice also significantly increased high-density lipoprotein cholesterol levels, improved the liver histopathology of rats by reducing the number of fat vacuoles and preventing hepatocyte damage. Conclusion Germination of IR-64 brown rice increased the TPC and antioxidant activity. It also helped maintain body weight, improved the lipid blood profile and MDA levels, and prevented histopathological damage.

Item Type:	Article
Subjects:	Medicine > RL Dermatology
Divisions:	Fakultas Teknik dan Ilmu Komputer > Program Studi Ilmu dan Teknologi Pangan
Depositing User:	Ahmad Yani
Date Deposited:	10 Oct 2024 06:20
Last Modified:	10 Oct 2024 06:20
URI:	https://repository.bakrie.ac.id/id/eprint/10996

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