Fermented Rice Bran Supplementation Prevents the Development of Intestinal Fibrosis Due to DSS-Induced Inflammation in Mice

Agista, Afifah Zahra and Rusbana, Tubagus Bahtiar and Islam, Jahidul and Ohsaki, Yusuke and Sultana, Halima and Hirakawa, Ryota and Watanabe, Kouichi and Nochi, Tomonori and Ardiansyah, Ardiansyah and Budijanto, Slamet and Yang, Suh-Ching and Koseki, Takuya and Aso, Hisashi and Komai, Michio and Shirakawa, Hitoshi (2021) Fermented Rice Bran Supplementation Prevents the Development of Intestinal Fibrosis Due to DSS-Induced Inflammation in Mice. Nutrients, 13 (6). p. 1869. ISSN 2072-6643

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Abstract

Fermented rice bran (FRB) is known to protect mice intestines against dextran sodium sulfate (DSS)-induced inflammation; however, the restoration of post-colitis intestinal homeostasis using FRB supplementation is currently undocumented. In this study, we observed the effects of dietary FRB supplementation on intestinal restoration and the development of fibrosis after DSS-induced colitis. DSS (1.5%) was introduced in the drinking water of mice for 5 days. Eight mice were sacrificed immediately after the DSS treatment ended. The remaining mice were divided into three groups, comprising the following diets: control, 10% rice bran (RB), and 10% FRB-supplemented. Diet treatment was continued for 2 weeks, after which half the population of mice from each group was sacrificed. The experiment was continued for another 3 weeks before the remaining mice were sacrificed. FRB supplementation could reduce the general observation of colitis and production of intestinal pro-inflammatory cytokines. FRB also increased intestinal mRNA levels of anti-inflammatory cytokine, tight junction, and anti-microbial proteins. Furthermore, FRB supplementation suppressed markers of intestinal fibrosis. This effect might have been achieved via the canonical Smad2/3 activation and the non-canonical pathway of Tgf-β activity. These results suggest that FRB may be an alternative therapeutic agent against inflammation-induced intestinal fibrosis

Item Type:	Article
Uncontrolled Keywords:	colitis; dextran sodium sulfate; fermented rice bran; intestinal fibrosis; intestinal inflammation
Subjects:	Food Science and Technology > Food Fermentation Food Science and Technology
Divisions:	Fakultas Teknik dan Ilmu Komputer > Program Studi Ilmu dan Teknologi Pangan
Depositing User:	Users 2 not found.
Date Deposited:	20 Jan 2022 04:01
Last Modified:	20 Jan 2022 04:01
URI:	https://repository.bakrie.ac.id/id/eprint/5635

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